Epigenetic Mechanisms in Head and Neck Cancer
نویسندگان
چکیده
Head and neck cancer (HNC) is one of the most prevalent human malignancies, af‐ fecting different anatomic sites of the upper aerodigestive tract (UADT) such as the oral cavity, larynx, and naso-, oro-, and hypopharynx. HNC develops through the ac‐ cumulation of multiple genetic and epigenetic alterations in a multistep process. In this issue, the aim is to describe epigenetic mechanisms behind HNC. The main mech‐ anisms evaluated are DNA methylation, posttranslational histone modification, and noncoding RNAs.
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درمان سرطان بر پایه اپی ژنتیک
Introduction: Epigenetics involves the study of heritable changes in the regulation of gene activity and expression that are not dependent on gene sequence. Main mechanisms of epigenetic modifications are DNA methylation, Histone modification and Nucleosome positioning. Several studies have shown that these modifications are related to cancer initiation, progression or tumor metastasis. In cont...
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